GLP-1 Analog

GLP-1 Analog – 10 mg / 20 mg

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

Sema is a long-acting, acylated GLP-1 receptor agonist peptide and structural analog of native glucagon-like peptide-1 (GLP-1). It is a 31-amino acid peptide modified with a C18 fatty diacid chain linked via a linker to lysine at position 26, conferring extended plasma half-life through albumin binding. Sema is widely used as a research tool for studying GLP-1 receptor (GLP-1R) signaling, incretin biology, and metabolic pathway regulation in preclinical in vitro models.

Specifications

• Quantity: 10 mg / 20 mg

• Form: Lyophilized Powder

• CAS: 910463-68-2

• Molecular Weight: 4,113.6 Da

• Purity: ≥99.4% (third-party verified)

• Storage: -20°C long-term; 4°C short-term (use within 4 weeks of reconstitution)

Research Context

Sema binds with high affinity to the GLP-1 receptor, a class B G protein-coupled receptor, activating adenylyl cyclase and downstream cAMP/PKA signaling cascades associated with insulin gene transcription, beta-cell proliferation, and apoptosis suppression in pancreatic cell lines. Research involving Sema has examined GLP-1R-mediated modulation of glucagon secretion, gastric emptying kinetics, and hypothalamic satiety signaling in in vitro and animal model systems. The extended half-life profile resulting from albumin binding makes it a valuable pharmacological probe for studying receptor occupancy duration and downstream signal persistence. It is also studied in the context of neuroinflammation and central nervous system GLP-1R distribution.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the U.S. Food and Drug Administration (FDA).

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Axis Peptide Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• All sales are final.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.