PT-141 and Melanotan II are both melanocortin peptides, but they are studied for different reasons. Melanotan II is an alpha-MSH analog studied in melanocortin receptor research; PT-141 (Bremelanotide) is a related melanocortin receptor agonist. Both are supplied for research use only.
Side by side
| PT-141 | Melanotan II | |
|---|---|---|
| Also known as | Bremelanotide | MT-II |
| Family | Melanocortin | Melanocortin |
| Based on | Melanocortin agonist | Alpha-MSH analog |
| Research focus | MC4R signaling | Non-selective MC1R-MC5R |
| Status | Research use only | Research use only |

Same family, different focus
Both belong to the melanocortin family and act as agonists in that system, which is why they are compared. The difference is in their research focus, with Melanotan II acting non-selectively across MC1R, MC3R, MC4R and MC5R.
What to look for
A research-grade compound should ship with a batch-specific certificate of analysis documenting identity and purity.
Key takeaways
- PT-141 and Melanotan II are both melanocortin peptides.
- Melanotan II is an alpha-MSH analog studied in melanocortin receptor research.
- PT-141 (Bremelanotide) is a related melanocortin agonist.
- Both are research compounds, supplied for research use only.
A note on research use
The peptides supplied by Axis Peptide Labs are reference compounds for laboratory and research use only. They are intended for qualified researchers working in academic, institutional, and analytical settings. They are not drugs, foods, cosmetics, or medical products, and they are not intended for human or veterinary consumption. Documented identity and documented purity are what matter most when sourcing a compound, both of which are published on the Axis certificates of analysis page.
