The Atlas Set – Tirzepatide 10 mg + MOTS-C 20 mg
For In Vitro Research Use Only
Not for Human or Veterinary Application
Set Overview
The Atlas Set combines two research tools that probe metabolic regulation through orthogonal mechanisms — receptor-mediated incretin signaling and mitochondrial-nuclear stress signaling. Tirzepatide is a 39-amino acid acylated peptide and dual co-agonist at the GIP and GLP-1 receptors, used to study cAMP-mediated incretin pathway integration in pancreatic, adipocyte, and hypothalamic models. MOTS-C is a 16-amino acid mitochondrial-derived peptide encoded within the 12S rRNA region of the mitochondrial genome, studied for AMPK pathway activation, mitochondrial-nuclear crosstalk, and metabolic substrate utilization regulation. Each component ships as its own individually-labeled vial of lyophilized powder, third-party verified at ≥99% purity.
Components
-
Tirzepatide — 10 mg · CAS 2023788-19-2 · MW 4,813.6 Da · Dual GIP / GLP-1 receptor co-agonist · Purity ≥99.4%
-
MOTS-C — 20 mg · CAS 1457525-01-7 · MW 2,174.6 Da · Sequence MRWQEMGYIFYPRKLR · Purity ≥99.4%
-
Form: Lyophilized Powder (each vial)
-
Storage: -20°C long-term; 4°C short-term (use within 4 weeks of reconstitution)
Research Context
Tirzepatide acts as a co-agonist at GIPR and GLP-1R, two class B G protein-coupled receptors involved in cAMP-mediated cascades that modulate insulin secretion, glucagon suppression, gastric motility, and adipocyte lipid metabolism. Research using tirzepatide as a pharmacological probe has examined receptor-bias profiling between GIPR and GLP-1R activation, pancreatic beta-cell function, and hypothalamic appetite-regulating circuitry in preclinical models. MOTS-C operates through a distinct mechanism: under metabolic stress conditions it translocates to the nucleus and modulates the AICAR / ZMP pathway, inhibiting de novo purine synthesis and driving downstream AMPK phosphorylation associated with glucose uptake, fatty acid oxidation, and mitochondrial biogenesis in skeletal muscle and adipocyte cultures. The pairing enables comparative study of receptor-driven and mitochondrial-derived metabolic signaling in the same experimental context, including interactions with the Nrf2 antioxidant response and insulin sensitivity pathways.
Intended Use
This set is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:
Regulatory Disclaimer
-
These compounds have not been evaluated by the U.S. Food and Drug Administration (FDA).
-
They are not intended to diagnose, treat, cure, or prevent any disease.
-
All handling and use must comply with applicable institutional, local, state, and federal regulations.
Terms of Sale
By purchasing from Axis Peptide Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledges that the products are for research use only.
-
All sales are final.
-
The purchaser assumes full responsibility for compliant handling, storage, and use.
-
Resale for human consumption is strictly prohibited.
