Tesamorelin (10mg)

Tesamorelin – 10 mg

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

Tesamorelin is a synthetic analog of endogenous GH-releasing hormone (GHRH) consisting of the full 44-amino acid sequence of human GHRH(1-44) conjugated at the N-terminus with a trans-3-hexenoic acid moiety. This N-terminal modification confers enhanced stability against dipeptidyl peptidase IV (DPP-IV) enzymatic cleavage while preserving full agonist activity at the GHRH receptor (GHRHR). Tesamorelin is used as a research tool for studying GHRHR activation, anterior pituitary somatotroph signaling, and hypothalamic-pituitary GH axis biology in in vitro research systems.

Specifications

• Quantity: 10 mg

• Form: Lyophilized Powder

• Structure: trans-3-Hexenoic acid–GHRH(1-44)-NH2

• CAS: 218949-48-5

• Molecular Weight: ~5,136 Da

• Purity: ≥99.4% (third-party verified)

• Storage: -20°C long-term; 4°C short-term (use within 4 weeks of reconstitution)

Research Context

Tesamorelin activates GHRHR through Gαs-coupled adenylyl cyclase stimulation, leading to cAMP/PKA-mediated phosphorylation of CREB and downstream GH gene transcription and secretion in anterior pituitary somatotroph cell models. The trans-3-hexenoic acid N-terminal modification has been characterized in published research as a strategy for conferring DPP-IV protease resistance, making tesamorelin a longer-acting GHRHR agonist relative to native GHRH(1-44) in cell culture contexts and a useful probe for receptor occupancy duration studies. Research involving tesamorelin has examined GHRHR-mediated downstream IGF-1 axis activation in hepatocyte culture systems, as well as the compound’s utility in comparative structure-activity relationship studies of GHRH analogs bearing N-terminal chemical modifications. It is also studied in the context of visceral adipose tissue lipolysis signaling pathways using adipocyte cell line models as a functional downstream readout of GH axis activation.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the U.S. Food and Drug Administration (FDA).

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Axis Peptide Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• All sales are final.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.