IGF-1 LR3 (1mg)

IGF-1 LR3 – 1 mg

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic 83-amino acid analog of native insulin-like growth factor-1 (IGF-1), incorporating a 13-amino acid N-terminal extension and a substitution of arginine for glutamic acid at position 3 of the mature IGF-1 sequence. These structural modifications result in significantly reduced binding affinity for IGF-binding proteins (IGFBPs), thereby extending the compound’s effective half-life in cell culture systems compared to native IGF-1. IGF-1 LR3 is used as a research tool for studying IGF-1 receptor (IGF-1R) signaling, PI3K/Akt/mTOR pathway activation, and insulin receptor cross-reactivity in vitro.

Specifications

• Quantity: 1 mg

• Form: Lyophilized Powder

• Structure: 83-AA IGF-1 analog (Arg3 substitution, 13-residue N-terminal extension)

• CAS: 946870-92-4

• Molecular Weight: ~9,111 Da

• Purity: ≥99.4% (third-party verified)

• Storage: -20°C long-term; 4°C short-term; avoid repeated freeze-thaw cycles

Research Context

IGF-1 LR3 activates the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase, initiating autophosphorylation of intracellular tyrosine residues and downstream activation of the PI3K/Akt/mTOR and Ras/MAPK/ERK signaling cascades, which are studied in the context of cell proliferation, protein synthesis regulation, and apoptosis suppression across a broad range of cell lines. The Arg3 substitution and N-terminal extension substantially reduce IGFBP-3 and IGFBP-5 binding affinity, making IGF-1 LR3 a preferred research tool over native IGF-1 for long-duration cell culture experiments where IGFBP-mediated sequestration would otherwise limit bioavailability. Published research has employed this analog to study myoblast differentiation, satellite cell activation, and skeletal muscle hypertrophy signaling in C2C12 cultures, as well as hepatocyte glucose uptake via GLUT4 translocation. It is also used in comparative receptor binding studies examining IGF-1R versus insulin receptor (IR) cross-reactivity and downstream signal divergence.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the U.S. Food and Drug Administration (FDA).

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Axis Peptide Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• All sales are final.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.