IGF-1 LR3

IGF-1 LR3 – 1 mg

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

IGF-1 LR3 (Long Arg3 IGF-1) is an 83-amino acid analog of insulin-like growth factor-1 with a 13-amino acid N-terminal extension and an arginine substitution at position 3. These changes greatly reduce its binding to IGF-binding proteins (IGFBPs), which extends its activity in cell culture. It is used as a research tool for studying IGF-1 receptor (IGF-1R) signaling in vitro.

Specifications

• Quantity: 1 mg

• Form: Lyophilized Powder

• Structure: 83-AA IGF-1 analog (Arg3 substitution, 13-residue N-terminal extension)

• Molecular Formula: C400H623N111O115S9

• CAS: 143045-27-6

• Molecular Weight: 9,115.6 Da

• Purity: Printed on the lot certificate

• Storage: -20°C long-term; 4°C short-term; avoid repeated freeze-thaw cycles

Research Context

IGF-1 LR3 activates IGF-1R, a receptor tyrosine kinase, triggering PI3K/Akt/mTOR and Ras/MAPK/ERK signaling, which are studied in the context of cell proliferation and protein synthesis regulation in cell lines. Its low IGFBP affinity makes it a preferred tool over native IGF-1 for long-duration cell culture experiments, and it is used in comparative studies of IGF-1R versus insulin receptor cross-reactivity.

Certificate of Analysis

Every lot is tested by an independent laboratory. The certificate for this product is shown on this page and on the Test Results page.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals. It is not a drug, food, or cosmetic and is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the U.S. Food and Drug Administration (FDA). It is not intended to diagnose, treat, cure, or prevent any disease.

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Axis Peptide Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.