Sermorelin

Sermorelin – 5 mg

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

Sermorelin (GHRH(1-29)NH2) is a synthetic 29-amino acid amidated peptide representing the biologically active N-terminal fragment of endogenous GH-releasing hormone (GHRH). It is the shortest fragment of GHRH retaining full receptor binding and activation capacity at the GH-releasing hormone receptor (GHRHR), a class B G protein-coupled receptor expressed primarily on somatotroph cells of the anterior pituitary. Sermorelin is used in research contexts involving hypothalamic-pituitary somatotropic axis signaling, GH secretagogue pharmacology, and pituitary cell biology.

Specifications

• Quantity: 5 mg

• Form: Lyophilized Powder

• Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2

• CAS: 86168-78-7

• Molecular Weight: 3,357.9 Da

• Purity: ≥99.4% (third-party verified)

• Storage: -20°C long-term; 4°C short-term (use within 4 weeks of reconstitution)

Research Context

Sermorelin activates GHRHR via Gαs-coupled cAMP/PKA signaling, leading to downstream activation of GH (GH) gene transcription and secretion from pituitary somatotroph cells in primary culture and cell line models. Research involving sermorelin has examined GHRHR signal transduction kinetics, pituitary somatotroph cell proliferation, and the modulation of GH pulsatility patterns in hypothalamic-pituitary organotypic cultures. It is also studied as a reference agonist for GHRHR receptor binding affinity assays and receptor occupancy studies, and has been used to probe the downstream IGF-1 axis in hepatocyte cell culture systems. Sermorelin’s shorter sequence relative to full-length GHRH(1-44) makes it a tractable research tool for structure-activity relationship studies of GHRHR N-terminal binding domain interactions.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the U.S. Food and Drug Administration (FDA).

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Axis Peptide Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• All sales are final.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.