Glutathione

Glutathione – 600 mg

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

Glutathione (GSH) is an endogenous tripeptide composed of γ-L-glutamyl-L-cysteinyl-glycine and is the most abundant low-molecular-weight thiol antioxidant found in mammalian cells. It functions as a central cofactor in cellular redox homeostasis, xenobiotic detoxification via glutathione S-transferase (GST) conjugation, and free radical scavenging through both enzymatic and non-enzymatic mechanisms. Glutathione is used extensively as a biochemical research reagent and as a reference compound in studies of oxidative stress, thiol biochemistry, and intracellular redox state quantification.

Specifications

• Quantity: 600 mg

• Form: Lyophilized Powder

• Sequence: γ-L-Glutamyl-L-cysteinyl-glycine

• CAS: 70-18-8

• Molecular Weight: 307.32 Da

• Purity: ≥99.4% (third-party verified)

• Storage: -20°C long-term; 4°C short-term; protect from light and oxidizing conditions

Research Context

Glutathione participates in cellular redox regulation through its reversible oxidation to glutathione disulfide (GSSG), a reaction catalyzed by glutathione peroxidase (GPx) in the presence of reactive oxygen species (ROS), and its regeneration by glutathione reductase (GR) using NADPH as electron donor. Research employing glutathione as a biochemical tool has examined its role in Nrf2/Keap1 pathway regulation, mercapturic acid pathway detoxification, and the maintenance of protein thiol redox status in various cell lines. It is studied in the context of mitochondrial membrane potential maintenance, apoptosis signaling through regulation of caspase activity, and ferroptosis resistance mechanisms linked to GPx4 activity. Glutathione depletion models using this compound as a reference are common in oxidative stress research across hepatocyte, neuronal, and immune cell systems.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the U.S. Food and Drug Administration (FDA).

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Axis Peptide Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• All sales are final.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.