Melanotan II (10mg)

Melanotan II – 10 mg

For In Vitro Research Use Only
Not for Human or Veterinary Application

Product Overview

Melanotan II (MT-II) is a synthetic cyclic lactam heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), an endogenous melanocortin peptide derived from pro-opiomelanocortin (POMC). MT-II acts as a non-selective agonist at melanocortin receptor subtypes MC1R, MC3R, MC4R, and MC5R, making it a widely used pharmacological tool for studying melanocortin system biology. It is researched in contexts including pigmentation signaling, central nervous system melanocortin circuitry, and receptor subtype selectivity profiling.

Specifications

• Quantity: 10 mg

• Form: Lyophilized Powder

• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

• CAS: 121062-08-6

• Molecular Weight: 1,024.2 Da

• Purity: ≥99.4% (third-party verified)

• Storage: -20°C long-term; 4°C short-term (use within 4 weeks of reconstitution)

Research Context

Melanotan II binds with high affinity to MC1R, MC3R, MC4R, and MC5R — G protein-coupled receptors that signal primarily through Gαs-mediated cAMP elevation. Its non-selectivity across receptor subtypes makes it a valuable comparative tool in studies seeking to delineate subtype-specific pharmacological effects, particularly in distinguishing MC4R-mediated hypothalamic signaling from MC1R-mediated melanocyte responses. Research involving MT-II has examined melanocortin receptor activation in the context of pigmentation biology, hypothalamic energy balance circuitry, and neuronal cAMP signaling in cell-based assays. The cyclic lactam structure confers enhanced receptor binding stability relative to linear α-MSH analogs, making it a commonly referenced compound in melanocortin receptor pharmacology literature.

Intended Use

This compound is intended strictly for in vitro laboratory research by qualified professionals.
It is not approved for:

• Human use

• Veterinary use

• Food, drug, diagnostic, or cosmetic applications

Regulatory Disclaimer

• This compound has not been evaluated by the U.S. Food and Drug Administration (FDA).

• It is sold strictly as a research material with no medical or therapeutic claims.

• All handling and use must comply with applicable institutional, local, state, and federal regulations.

Terms of Sale

By purchasing from Axis Peptide Labs, the buyer confirms that they are a qualified researcher, laboratory, or institution and acknowledge that the product is for research use only.

• All sales are final.

• The purchaser assumes full responsibility for compliant handling, storage, and use.

• Resale for human consumption is strictly prohibited.